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Anti-AIF Polyclonal Antibody
產(chǎn)品簡介：

Anti-AIF Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K106588P

更新時間：2022-08-15

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產(chǎn)品介紹

Anti-AIF Polyclonal Antibody

英文名稱Anti-AIF Polyclonal Antibody
宿主Rabbit
別名AIFM1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8
應(yīng)用WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human Mouse Rat
蛋白分子量66kDa
Gene ID9131
保存Store at -20°C. Avoid freeze / thaw cycles.
儲存液Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法Affinity purification
亞型IgG
免疫原Recombinant protein of human AIF
性狀液體
Public Immunogen RangeRecombinant protein of human AIF
Subcellular LocationsCytoplasm
Swiss ProtO95831
克隆類型Polyclonal Antibody
背景資料Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.

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